DOTD-Ceftriaxone (rocephin)

Ceftriaxone (Rocephin) is an intravenous/intramuscular third generation cephalosporin that provides decent aerobic gram positive coverage (ie, pneumococcus although bacterial resistance is growing) but wonderful gram negative coverage against organisms like E. coli, Klebsiella, H. flu, and Proteus. Anaerobic bacteria and Pseudomonas are NOT covered by ceftriaxone. πŸ€“πŸ’‰
As an intensivist, I use this antibiotic in a myriad of clinical situations ranging from spontaneous bacterial peritonitis (SBP) prophylaxis and community acquired pneumonia to genitourinary infections and meningitis (even late Lyme disease involving the central nervous system as ceftriaxone as penetrates the cerebrospinal fluid very well). 😷🧠
Similar to cefepime, ceftriaxone can also cause encephalopathy and altered mentation. Additionally, one must be aware of possible hepatobiliary impairment due to biliary sludging and cholecystitis. πŸ‘¨πŸ½β€βš•οΈπŸ₯
My favorite aspect of using ceftriaxone is that it can usually be dosed once-a-day (a key exception being meningeal dosing which is twice daily). 😊

About the Author
I am an experienced trauma nurse who has seen a lot of super tragic and gnarly things. On the flip side, I’ve have seen and done a lot of amazing things in my 20 years of nursing as well. I’ve saved lives for a living and I have had the privilege and the honor of holding patients hands as they take their last breath. I have seen SO many patients and their loved ones in their most fragile moments. I am proud of my profession, and for the fact that I have fought so valiantly to be here. Sometimes nurses get burnt out, but I have been blessed to be at the bedside all of my career. I have earned multiple degrees and certifications in nursing. I am the nurse you want at your bedside when you’re critically injured and dying. I put my blood, sweat and tears into being clinically astute & relevant. This blog is to help new nurses, nursing students, paramedics, experienced nurses, or whomever comes across my blogs path and think it is intriguing, educational or inspiring to them. In this career, we are all here to share and help one another grow. I believe in building others up, so they can reach the next level, whatever their goal may be. Carpe Diem & ENJOY!

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